COMPUTATIONAL BIOPHYSICS

TOXIN BINDING:

VIDEO CLIPS: These video clips are in WMV format.  1. Spider toxin GsMTx4 binding to POPC

THE CLC CHANNEL:

VIDEO CLIPS: These video clips are in mp4 format.  1. Crystal Structure of the Bacterial ClC Channel  2. Blocked Pore  3. Remodelling Open-State ClC Channel  4. Open-State Pore  5. Converting ClC channel into ClC-0 and ClC-1  6. Brownian Dynamics Simulations  7. Conductance properties of ClC-0 and ClC-1  8. Testable Predictions  9. Possible Gating Mechanism

THE POTASSIUM CHANNEL:

VIDEO CLIPS:   ( See BBA 1565, 267, 2002 ) These video clips are in mp4 format.  1. The Potassium Channel Structure  2. Selectivity of the Potassium Channel  3. Electrostatic Calculations  4. Brownian Dynamics Simulations

TEA BLOCK OF POTASSIUM CHANNEL:

VIDEO CLIPS: These video clips are in mp4 format.  1. Intracellular TEA Block of Potassium Channel

BARIUM BLOCK:

VIDEO CLIPS: These video clips are in mp4 format.  1. Internal TEA Block  2. External TEA Block

THE CALCIUM CHANNEL: Permeation and Selecitivty of the Calcium Channel

VIDEO CLIPS: These video clips are in mp4 format.  1. Channel Geometry  2. Single Ion Species - Electrostatic Calculations  3. Single Ion Species - Brownian Dynamics Simulations  4. Mixture of Ions - Electrostatic Calculations  5. Mixture of Ions - Brownian Dynamics Simulations  6. Comparison with Experimental Results

THE SODIUM CHANNEL:

VIDEO CLIPS: These video clips are in mp4 format.  1. Spontaneous binding of the conotoxin PIIIA to the bacterial sodium channel NavAb (1)  2. Spontaneous binding of the conotoxin PIIIA to the bacterial sodium channel NavAb (2)